Abstract
Background The Hyperhidrosis Quality of Life Index (HidroQoL (c)) is a validated patient-reported outcome measure capturing the quality of life of people affected by hyperhidrosis. Objectives We aimed to extend the validity evidence to physician-confirmed diagnosis of primary axillary hyperhidrosis. Methods Data from a phase III randomized placebo-controlled clinical trial were used (n= 171). ...
Abstract
Background The Hyperhidrosis Quality of Life Index (HidroQoL (c)) is a validated patient-reported outcome measure capturing the quality of life of people affected by hyperhidrosis. Objectives We aimed to extend the validity evidence to physician-confirmed diagnosis of primary axillary hyperhidrosis. Methods Data from a phase III randomized placebo-controlled clinical trial were used (n= 171). Confirmatory factor analysis was carried out to confirm the a priori two-factor structure of the HidroQoL. Internal consistency was assessed using Cronbach's alpha. Intraclass correlation coefficients (ICCs) were calculated to evaluate test-retest reliability after days -7 to -4. Convergent validity was assessed using correlations with the Dermatology Life Quality Index (DLQI), the Hyperhidrosis Disease Severity Scale (HDSS) and gravimetric sweat production. Known groups were analysed to evaluate discriminative validity. Responsiveness after 29 days was assessed and minimal important difference (MID) values were calculated using both anchor- and distribution-based approaches. All analyses were carried out for total HidroQoL and its two domains. Results The two-factor structure of the HidroQoL was confirmed. Internal consistency and test-retest reliability were strong (Cronbach's alpha 0 center dot 81-0 center dot 90; ICCs 0 center dot 89-0 center dot 93). Correlations with other outcome measures were in line with a priori hypotheses. The HidroQoL discriminated between different severity groups (P <= 0 center dot 001) and showed sensitivity to change towards improvement (P< 0 center dot 001). An MID value of 4 is proposed for the total scale. Conclusions This study supports excellent measurement properties including clinical applicability of the HidroQoL in primary axillary hyperhidrosis and suggests a MID of 4 be applied to clinical trial data.
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