Final results of the PräVAC trial: prevention of wound complications following inguinal lymph node dissection in patients with penile cancer using epidermal vacuum-assisted wound closure

URN to cite this document:

urn:nbn:de:bvb:355-epub-508071 Copy

DOI to cite this document:

10.5283/epub.50807 Copy

Schmid, Sebastian C. ; Seitz, Anna K. ; Haller, Bernhard ; Fritsche, Hans-Martin ; Huber, Toni ; Burger, Maximilian ; Gschwend, Jürgen E. ; Maurer, Tobias

License: Creative Commons Attribution 4.0 PDF - Published Version (758kB)

Date of publication of this fulltext: 11 Oct 2021 13:28

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Details

Item type:	Article
Open Access Type:	DEAL (Springer) - Non UR
Journal or Publication Title:	World Journal of Urology
Publisher:	Springer
Place of Publication:	NEW YORK
Volume:	39
Number of Issue or Book Chapter:	2
Page Range:	pp. 613-620
Date:	5 May 2020
Institutions:	Medicine > Lehrstuhl für Urologie
Identification Number:	Value Type 10.1007/s00345-020-03221-z DOI
Keywords:	SQUAMOUS-CELL CARCINOMA; LYMPHADENECTOMY; BIOPSY; MANAGEMENT; MORBIDITY; Inguinal surgery; Penile cancer; Lymphorrhea; PraeVac; Closed incision negative pressure
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	50807

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Abstract

Purpose Inguinal lymphadenectomy in penile cancer is associated with a high rate of wound complications. The aim of this trial was to prospectively analyze the effect of an epidermal vacuum wound dressing on lymphorrhea, complications and reintervention in patients with inguinal lymphadenectomy for penile cancer. Patients and methods Prospective, multicenter, randomized, investigator-initiated ...

Abstract

Purpose Inguinal lymphadenectomy in penile cancer is associated with a high rate of wound complications. The aim of this trial was to prospectively analyze the effect of an epidermal vacuum wound dressing on lymphorrhea, complications and reintervention in patients with inguinal lymphadenectomy for penile cancer. Patients and methods Prospective, multicenter, randomized, investigator-initiated study in two German university hospitals (2013-2017). Thirty-one patients with penile cancer and indication for bilateral inguinal lymph node dissection were included and randomized to conventional wound care on one side (CONV) versus epidermal vacuum wound dressing (VAC) on the other side. Results A smaller cumulative drainage fluid volume until day 14 (CDF) compared to contralateral side was observed in 15 patients (CONV) vs. 16 patients (VAC), with a median CDF 230 ml (CONV) vs. 415 ml (VAC) and a median maximum daily fluid volume (MDFV) of 80 ml (CONV) vs. 110 ml (VAC). Median time of indwelling drainage: 7 days (CONV) vs. 8 days (VAC). All grade surgery-related complications were seen in 74% patients (CONV) vs. 74% patients (VAC); grade 3 complications in 3 patients (CONV) vs. 6 patients (VAC). Prolonged hospital stay occurred in 32% patients (CONV) vs. 48% patients (VAC); median hospital stay was 11.5 days. Reintervention due to complications occurred in 45% patients (CONV) vs. 42% patients (VAC). Conclusions In this prospective, randomized trial we could not observe a significant difference between epidermal vacuum treatment and conventional wound care.

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Metadata last modified: 25 Apr 2024 09:37

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