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Development of radioligand binding and functional assays for the characterization of dopamine D2-like receptor ligands

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Forster, Lisa
Date of publication of this fulltext: 04 Oct 2022 08:06

Abstract (English)

The family of dopamine D2-like receptors comprises the D2, D3 and D4 receptor, which exist in different isoforms, due to alternative splicing of the mRNA or polymorphisms in the coding sequence for the respective receptor. The D2-like receptors are implicated in various pathological conditions, such as schizophrenia, Parkinson’s disease, substance abuse or attention deficit hyperactivity disorder ...


Translation of the abstract (German)

Die Dopamin D2-Rezeptorfamilie umfasst den D2, D3 und D4-Rezeptor, die aufgrund von alternativem Splicing der mRNA oder Polymorphismen in der kodierenden Sequenz für den jeweiligen Rezeptor in verschiedenen Isoformen existieren. Die D2-artigen Rezeptoren sind an verschiedenen pathologischen Zuständen beteiligt, wie z. B. Schizophrenie, Parkinson, Drogenmissbrauch oder ...


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