| Download ( PDF | 1MB) | License: Creative Commons Attribution 4.0 |
Owner only: item control page
Kardiales ROS-Signaling bei akuter Vorlasterhöhung am Working Heart Model
Schmidtke, Konstantin Johannes (2021) Kardiales ROS-Signaling bei akuter Vorlasterhöhung am Working Heart Model. PhD, Universität Regensburg.Date of publication of this fulltext: 02 Nov 2021 11:17
Thesis of the University of Regensburg
DOI to cite this document: 10.5283/epub.50904
Abstract (German)
Über reaktive Sauerstoffspezies (ROS) ist schon länger bekannt, dass sie neben ihrer zellschädigenden Wirkung auch als Signalmoleküle fungieren können. Dies geschieht vorwiegend über posttranslationale Modifikation, genauer gesagt über Thiol-Gruppen. Ziel dieser Arbeit war - auf Grundlage eines Working
Heart Models an murinen Herzen verschiedener Genotypen - ein Screening auf solche RedOx-sensitive Proteine, die bei akuter Vor-, respektive Nachlasterhöhung eine solches ROS-Signal übertragen.
Translation of the abstract (English)
Reactive oxygen species are longer known for their cell-damaging effect but also as signaling molecules. Especially
proteins with thiol groups which can be oxydized or deoxidiced can lead such an intracellular signal. The aim of this work was - based on a working heart model of genetically different murine hearts - a screening for such redox-sensitive proteins which could transmit ROS-Signaling during acute increase of preload or afterload.
Involved Institutions
Details
| Item type | Thesis of the University of Regensburg (PhD) |
| Open Access Type: | Primary Publication |
|---|---|
| Date | 2 November 2021 |
| Referee | Prof. Dr. Lars Maier |
| Date of exam | 21 October 2021 |
| Institutions | Medicine > Lehrstuhl für Innere Medizin II |
| Keywords | reactive oxygen species, preload, afterload, murine hearts, working heart model, mitochondrial transhydrogenase |
| Dewey Decimal Classification | 600 Technology > 610 Medical sciences Medicine |
| Status | Published |
| Refereed | Yes, this version has been refereed |
| Created at the University of Regensburg | Yes |
| URN of the UB Regensburg | urn:nbn:de:bvb:355-epub-509048 |
| Item ID | 50904 |
Export bibliographical data
Owner only: item control page
Download Statistics
Download Statistics