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The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model

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Talbi, Khaoula ; Cabrita, Inês ; Kraus, Andre ; Hofmann, Sascha ; Skoczynski, Kathrin ; Kunzelmann, Karl ; Buchholz, Bjoern ; Schreiber, Rainer
Date of publication of this fulltext: 09 Dec 2021 05:50

This publication is part of the DEAL contract with Wiley.


Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of bilateral renal cysts which enlarge continuously, leading to compression of adjacent intact nephrons. The growing cysts lead to a progressive decline in renal function. Cyst growth is driven by enhanced cell proliferation and chloride secretion into the cyst lumen. Chloride secretion is believed to occur ...


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