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The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model

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Talbi, Khaoula ; Cabrita, Inês ; Kraus, Andre ; Hofmann, Sascha ; Skoczynski, Kathrin ; Kunzelmann, Karl ; Buchholz, Bjoern ; Schreiber, Rainer
Date of publication of this fulltext: 09 Dec 2021 05:50


Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of bilateral renal cysts which enlarge continuously, leading to compression of adjacent intact nephrons. The growing cysts lead to a progressive decline in renal function. Cyst growth is driven by enhanced cell proliferation and chloride secretion into the cyst lumen. Chloride secretion is believed to occur ...


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