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The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model

URN to cite this document:
urn:nbn:de:bvb:355-epub-511633
DOI to cite this document:
10.5283/epub.51163
Talbi, Khaoula ; Cabrita, Inês ; Kraus, Andre ; Hofmann, Sascha ; Skoczynski, Kathrin ; Kunzelmann, Karl ; Buchholz, Bjoern ; Schreiber, Rainer
Date of publication of this fulltext: 09 Dec 2021 05:50


Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of bilateral renal cysts which enlarge continuously, leading to compression of adjacent intact nephrons. The growing cysts lead to a progressive decline in renal function. Cyst growth is driven by enhanced cell proliferation and chloride secretion into the cyst lumen. Chloride secretion is believed to occur ...

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