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Comparative Plasma and Interstitial Tissue Fluid Pharmacokinetics of Meropenem Demonstrate the Need for Increasing Dose and Infusion Duration in Obese and Non-obese Patients

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Busse, David ; Simon, Philipp ; Schmitt, Lisa ; Petroff, David ; Dorn, Christoph ; Dietrich, Arne ; Zeitlinger, Markus ; Huisinga, Wilhelm ; Michelet, Robin ; Wrigge, Hermann ; Kloft, Charlotte
License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 17 Dec 2021 11:38


Background and objectives: A quantitative evaluation of the PK of meropenem, a broad-spectrum β-lactam antibiotic, in plasma and interstitial space fluid (ISF) of subcutaneous adipose tissue of obese patients is lacking as of date. The objective of this study was the characterisation of meropenem population pharmacokinetics in plasma and ISF in obese and non-obese patients for identification of ...


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