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Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo

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Siska, Peter J. ; Jiao, Jing ; Matos, Carina ; Singer, Katrin ; Berger, Raffaela S. ; Dettmer, Katja ; Oefner, Peter J. ; Cully, Michelle D. ; Wang, Zhonglin ; Quinn III, William J. ; Oliff, Kristen N. ; Wilkins, Benjamin J. ; Christensen, Lanette M. ; Wang, Liqing ; Hancock, Wayne W. ; Baur, Joseph A. ; Levine, Matthew H. ; Ugele, Ines ; Mayr, Roman ; Renner, Kathrin ; Zhou, Liang ; Kreutz, Marina ; Beier, Ulf H.
Date of publication of this fulltext: 20 Dec 2021 08:49


Background: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce less neurotoxic metabolites than L-kynurenine. Methods: L-/D-kynurenine effects on human and murine T cell function were examined in vitro and in vivo ...


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