Go to content
UR Home

Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo

URN to cite this document:
urn:nbn:de:bvb:355-epub-512421
DOI to cite this document:
10.5283/epub.51242
Siska, Peter J. ; Jiao, Jing ; Matos, Carina ; Singer, Katrin ; Berger, Raffaela S. ; Dettmer, Katja ; Oefner, Peter J. ; Cully, Michelle D. ; Wang, Zhonglin ; Quinn III, William J. ; Oliff, Kristen N. ; Wilkins, Benjamin J. ; Christensen, Lanette M. ; Wang, Liqing ; Hancock, Wayne W. ; Baur, Joseph A. ; Levine, Matthew H. ; Ugele, Ines ; Mayr, Roman ; Renner, Kathrin ; Zhou, Liang ; Kreutz, Marina ; Beier, Ulf H.
Date of publication of this fulltext: 20 Dec 2021 08:49


Abstract

Background: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce less neurotoxic metabolites than L-kynurenine. Methods: L-/D-kynurenine effects on human and murine T cell function were examined in vitro and in vivo ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons