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CD47 is expressed at normal levels in patients with autoimmune haemolytic anaemia and/or immune thrombocytopenia

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Ahrens, Norbert ; Pagenkopf, C. ; Kiesewetter, H. ; Salama, A.
Date of publication of this fulltext: 18 Jan 2022 05:39


CD47 deficiency results in lethal autoimmune haemolytic anaemia (AIHA) and mild spontaneous thrombocytopenia in non-obese diabetic mice. It is unknown whether CD47 has an impact on AIHA of the warm type or autoimmune thrombocytopenia (ITP) in humans. Healthy blood donors (n= 11), patients with AIHA (n= 13), patients with ITP (n= 18) and one patient with Rhnull phenotype were investigated. CD47 ...


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