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B‐cell modulation with anti‐CD79b antibodies ameliorates experimental autoimmune encephalitis in mice

URN to cite this document:
urn:nbn:de:bvb:355-epub-513851
DOI to cite this document:
10.5283/epub.51385
Renner, Kerstin ; Neumayer, Sophia ; Talke, Yvonne ; Buchtler, Simone ; Schmidbauer, Kathrin ; Nimmerjahn, Falk ; Lux, Anja ; Winter, Frederike ; Salewski, Jan‐Nicklas ; Mack, Matthias
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Jan 2022 05:36

This publication is part of the DEAL contract with Wiley.


Abstract

B cells play a major role in the pathogenesis of many autoimmune diseases like MS, rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for MS. However, total B-cell depletion will also affect regulatory B cells that are known to suppress autoimmune responses. In our studies, we describe an alternative approach based on ...

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