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B‐cell modulation with anti‐CD79b antibodies ameliorates experimental autoimmune encephalitis in mice

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Renner, Kerstin ; Neumayer, Sophia ; Talke, Yvonne ; Buchtler, Simone ; Schmidbauer, Kathrin ; Nimmerjahn, Falk ; Lux, Anja ; Winter, Frederike ; Salewski, Jan‐Nicklas ; Mack, Matthias
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Date of publication of this fulltext: 13 Jan 2022 05:36

This publication is part of the DEAL contract with Wiley.


B cells play a major role in the pathogenesis of many autoimmune diseases like MS, rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for MS. However, total B-cell depletion will also affect regulatory B cells that are known to suppress autoimmune responses. In our studies, we describe an alternative approach based on ...


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