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Spectrum Bias and Individual Strengths of SARS-CoV-2 Serological Tests—A Population-Based Evaluation

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Einhauser, Sebastian ; Peterhoff, David ; Niller, Hans Helmut ; Beileke, Stephanie ; Günther, Felix ; Steininger, Philipp ; Burkhardt, Ralph ; Heid, Iris M. ; Pfahlberg, Annette B. ; Überla, Klaus ; Gefeller, Olaf ; Wagner, Ralf
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Jan 2022 15:30


Antibody testing for determining the SARS-CoV-2 serostatus was rapidly introduced in early 2020 and since then has been gaining special emphasis regarding correlates of protection. With limited access to representative samples with known SARS-CoV-2 infection status during the initial period of test development and validation, spectrum bias has to be considered when moving from a "test ...


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