Spectrum Bias and Individual Strengths of SARS-CoV-2 Serological Tests—A Population-Based Evaluation

URN to cite this document:: urn:nbn:de:bvb:355-epub-514089
DOI to cite this document:: 10.5283/epub.51408

Einhauser, Sebastian

; Peterhoff, David

; Niller, Hans Helmut ; Beileke, Stephanie ; Günther, Felix ; Steininger, Philipp ; Burkhardt, Ralph

; Heid, Iris M. ; Pfahlberg, Annette B.

; Überla, Klaus

; Gefeller, Olaf

; Wagner, Ralf

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Date of publication of this fulltext: 12 Jan 2022 15:30

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Abstract

Antibody testing for determining the SARS-CoV-2 serostatus was rapidly introduced in early 2020 and since then has been gaining special emphasis regarding correlates of protection. With limited access to representative samples with known SARS-CoV-2 infection status during the initial period of test development and validation, spectrum bias has to be considered when moving from a "test ...