Chemerin Overexpression in the Liver Protects against Inflammation in Experimental Non-Alcoholic Steatohepatitis

URN to cite this document:: urn:nbn:de:bvb:355-epub-514481
DOI to cite this document:: 10.5283/epub.51448

Pohl, Rebekka ; Feder, Susanne ; Haberl, Elisabeth M.

; Rein-Fischboeck, Lisa ; Weiss, Thomas S.

; Spirk, Marlen ; Bruckmann, Astrid ; McMullen, Nichole

; Sinal, Christopher J. ; Buechler, Christa

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Date of publication of this fulltext: 18 Jan 2022 12:56

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Abstract

Non-alcoholic steatohepatitis (NASH) is marked by macrophage infiltration and inflammation. Chemerin is a chemoattractant protein and is abundant in hepatocytes. The aim of this study was to gain insight into the role of hepatocyte-produced prochemerin in NASH. Therefore, mice were infected with adeno-associated virus 8 to direct hepatic overexpression of prochemerin in a methionine-choline ...