| Lizenz: Creative Commons Namensnennung 4.0 International PDF - Veröffentlichte Version (35MB) |
- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-514699
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.51469
Zusammenfassung
Signaling via death receptor family members such as TNF-R1 mediates pleiotropic biological outcomes ranging from inflammation and proliferation to cell death. Pro-survival signaling is mediated via TNF-R1 complex I at the cellular plasma membrane. Cell death induction requires complex IIa/b or necrosome formation, which occurs in the cytoplasm. In many cell types, full apoptotic or necroptotic ...
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