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β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis

URN to cite this document:
urn:nbn:de:bvb:355-epub-515507
DOI to cite this document:
10.5283/epub.51550
Rösch, Gundula ; Muschter, Dominique ; Taheri, Shahed ; El Bagdadi, Karima ; Dorn, Christoph ; Meurer, Andrea ; Zaucke, Frank ; Schilling, Arndt F. ; Grässel, Susanne ; Straub, Rainer H. ; Jenei-Lanzl, Zsuzsa
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Date of publication of this fulltext: 01 Feb 2022 08:15


Abstract

Purpose: Recent studies demonstrated a contribution of adrenoceptors (ARs) to osteoarthritis (OA) pathogenesis. Several AR subtypes are expressed in joint tissues and the β2-AR subtype seems to play a major role during OA progression. However, the importance of β2-AR has not yet been investigated in knee OA. Therefore, we examined the development of knee OA in β2-AR-deficient (Adrb2-/- ) mice ...

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