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Physiological levels of 25‐hydroxyvitamin D₃ induce a suppressive CD4⁺ T cell phenotype not reflected in the epigenetic landscape

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Matos, Carina ; Renner, Kathrin ; Peuker, Alice ; Schoenhammer, Gabriele ; Schreiber, Laura ; Bruss, Christina ; Eder, Ruediger ; Bruns, Heiko ; Flamann, Cindy ; Hoffmann, Petra ; Gebhard, Claudia ; Herr, Wolfgang ; Rehli, Michael ; Peter, Katrin ; Kreutz, Marina
License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 08 Feb 2022 06:27

This publication is part of the DEAL contract with Wiley.


1,25-dihydroxyvitamin D3 (1,25(OH)(2)D-3), the active metabolite of vitamin D3 has a strong impact on the differentiation and function of immune cells. Here we analysed the influence of its precursor 25-hydroxyvitamin D3 (25(OH)D-3) on the differentiation of human CD4(+) T cells applying physiological concentrations in vitro. Our data show that 25(OH)D-3 is converted to its active form ...


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