Physiological levels of 25‐hydroxyvitamin D₃ induce a suppressive CD4⁺ T cell phenotype not reflected in the epigenetic landscape

URN to cite this document:: urn:nbn:de:bvb:355-epub-515900
DOI to cite this document:: 10.5283/epub.51590

Matos, Carina

; Renner, Kathrin

; Peuker, Alice ; Schoenhammer, Gabriele ; Schreiber, Laura ; Bruss, Christina ; Eder, Ruediger ; Bruns, Heiko ; Flamann, Cindy ; Hoffmann, Petra ; Gebhard, Claudia

; Herr, Wolfgang ; Rehli, Michael ; Peter, Katrin

; Kreutz, Marina

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Date of publication of this fulltext: 08 Feb 2022 06:27

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Abstract

1,25-dihydroxyvitamin D3 (1,25(OH)(2)D-3), the active metabolite of vitamin D3 has a strong impact on the differentiation and function of immune cells. Here we analysed the influence of its precursor 25-hydroxyvitamin D3 (25(OH)D-3) on the differentiation of human CD4(+) T cells applying physiological concentrations in vitro. Our data show that 25(OH)D-3 is converted to its active form ...