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Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis

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Noda, Kentaro ; Dufner, Bianca ; Ito, Haruyasu ; Yoshida, Ken ; Balboni, Gianfranco ; Straub, Rainer H.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 17 Feb 2022 13:32


Prokineticin 2 (PK2) is a secreted protein involved in several pathological and physiological processes, including the regulation of inflammation, sickness behaviors, and circadian rhythms. Recently, it was reported that PK2 is associated with the pathogenesis of collagen-induced arthritis in mice. However, the role of PK2 in the pathogenesis of rheumatoid arthritis (RA) or osteoarthritis (OA) ...


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