Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis

URN to cite this document:: urn:nbn:de:bvb:355-epub-515946
DOI to cite this document:: 10.5283/epub.51594

Noda, Kentaro

; Dufner, Bianca ; Ito, Haruyasu ; Yoshida, Ken ; Balboni, Gianfranco

; Straub, Rainer H.

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Date of publication of this fulltext: 17 Feb 2022 13:32

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Abstract

Prokineticin 2 (PK2) is a secreted protein involved in several pathological and physiological processes, including the regulation of inflammation, sickness behaviors, and circadian rhythms. Recently, it was reported that PK2 is associated with the pathogenesis of collagen-induced arthritis in mice. However, the role of PK2 in the pathogenesis of rheumatoid arthritis (RA) or osteoarthritis (OA) ...