Improved Spectral Purity of 222‐nm Irradiation Eliminates Detectable Cyclobutylpyrimidine Dimers Formation in Skin Reconstructs even at High and Repetitive Disinfecting Doses

URN to cite this document:: urn:nbn:de:bvb:355-epub-516299
DOI to cite this document:: 10.5283/epub.51629

Ivanova, Irina

; Svilenska, Teodora ; Kurz, Bernadett ; Grobecker, Sonja ; Maisch, Tim

; Berneburg, Mark

; Kamenisch, York

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Date of publication of this fulltext: 10 Feb 2022 08:20

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Abstract

UVC222 nm has germicidal effects with potential clinical applications. However, UVC irradiation is capable of inducing DNA damage like cyclobutylpyrimidine dimers (CPD). Although new devices have emission peaks in the short-wavelength region of UVC (similar to 222 nm), the remaining "collateral" radiation at longer wavelengths could be harmful to human health. We investigated the DNA damage ...