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Influence of tedizolid on the cytokine response to the endotoxin challenge in healthy volunteers: a cross-over trial

Jorda, Anselm ; Wulkersdorfer, Beatrix ; Schörgenhofer, Christian ; Matzneller, Peter ; Al Jalali, Valentin ; Bauer, Martin ; Wölf-Duchek, Michael ; Lackner, Edith ; Dorn, Christoph ; Jilma, Bernd ; Zeitlinger, Markus



Abstract

Background: Preclinical data suggested anti-inflammatory properties of tedizolid. Objectives: To investigate the influence of tedizolid on the cytokine response to the human endotoxin challenge and the effect of endotoxaemia on the pharmacokinetics and protein binding of tedizolid. Methods: In this cross-over trial, 14 male healthy volunteers underwent two treatment periods: (A) 200 mg of ...

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