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Curcumin-primed human BMSC-derived extracellular vesicles reverse IL-1β-induced catabolic responses of OA chondrocytes by upregulating miR-126-3p

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Li, Shushan ; Stöckl, Sabine ; Lukas, Christoph ; Herrmann, Marietta ; Brochhausen, Christoph ; König, Matthias A. ; Johnstone, Brian ; Grässel, Susanne
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 17 Feb 2022 14:44


Background Curcumin has anti-inflammatory effects and qualifies as a potential candidate for the treatment of osteoarthritis (OA). However, curcumin has limited bioavailability. Extracellular vesicles (EVs) are released by multiple cell types and act as molecule carrier during intercellular communication. We assume that EVs can maintain bioavailability and stability of curcumin after ...


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