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Enhanced Cardiac CaMKII Oxidation and CaMKII-Dependent SR Ca Leak in Patients with Sleep-Disordered Breathing

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Arzt, Michael ; Drzymalski, Marzena A. ; Ripfel, Sarah ; Meindl, Sebastian ; Biedermann, Alexander ; Durczok, Melanie ; Keller, Karoline ; Mustroph, Julian ; Katz, Sylvia ; Tafelmeier, Maria ; Lebek, Simon ; Flörchinger, Bernhard ; Camboni, Daniele ; Wittmann, Sigrid ; Backs, Johannes ; Schmid, Christof ; Maier, Lars S. ; Wagner, Stefan
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 28 Mar 2022 15:17


Background: Sleep-disordered breathing (SDB) is associated with increased oxidant generation. Oxidized Ca/calmodulin kinase II (CaMKII) can contribute to atrial arrhythmias by the stimulation of sarcoplasmic reticulum Ca release events, i.e., Ca sparks. Methods: We prospectively enrolled 39 patients undergoing cardiac surgery to screen for SDB and collected right atrial appendage biopsies. ...


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