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An Evaluation of Different 3D Cultivation Models on Expression Profiles of Human Periodontal Ligament Fibroblasts with Compressive Strain

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Schröder, Agnes ; Schöniger, Ricarda ; Oeldemann, Juliane ; Spanier, Gerrit ; Proff, Peter ; Jantsch, Jonathan ; Kirschneck, Christian ; Ullrich, Niklas
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 28 Mar 2022 15:28


The effects of compressive strain during orthodontic treatment on gene expression profiles of periodontal ligament fibroblasts (PDLFs) have mostly been studied in 2D cell culture. However, cells behave differently in many aspects in 3D culture. Therefore, the effect of pressure application on PDLFs in different 3D structures was investigated. PDLFs were either conventionally seeded or embedded ...


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