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The Drosophila functional Smad suppressing element fuss, a homologue of the human Skor genes, retains pro-oncogenic properties of the Ski/Sno family

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Rass, Mathias ; Gizler, Laura ; Bayersdorfer, Florian ; Irlbeck, Christoph ; Schramm, Matthias Josef ; Schneuwly, Stephan
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 14 Mar 2022 16:50


Over the years Ski and Sno have been found to be involved in cancer progression e.g. in oesophageal squamous cell carcinoma, melanoma, oestrogen receptor-positive breast carcinoma, colorectal carcinoma, and leukaemia. Often, their prooncogenic features have been linked to their ability of inhibiting the anti-proliferative action of TGF-beta signalling. Recently, not only pro-oncogenic but also ...


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