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Sympathectomy aggravates subchondral bone changes during osteoarthritis progression in mice without affecting cartilage degeneration or synovial inflammation

Rösch, Gundula ; El Bagdadi, Karima ; Muschter, Dominique ; Taheri, Shahed ; Dorn, Christoph ; Meurer, Andrea ; Straub, Rainer H. ; Zaucke, Frank ; Schilling, Arndt F. ; Grässel, Susanne ; Jenei-Lanzl, Zsuzsa

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Objective: Osteoarthritis (OA) pathogenesis involves the interaction of articular cartilage with surrounding tissues, which are innervated by tyrosine hydroxylase-positive (TH+) sympathetic nerve fibers suggesting a role of the sympathetic nervous system (SNS) during OA progression. We analyzed the effects of sympathectomy (Syx) in a murine OA model. Methods: Peripheral Syx was generated by ...


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