Angiopoietin-1 Mimetic Nanoparticles for Restoring the Function of Endothelial Cells as Potential Therapeutic for Glaucoma

URN to cite this document:: urn:nbn:de:bvb:355-epub-519852
DOI to cite this document:: 10.5283/epub.51985

Mietzner, Raphael

; Pawlak, Ramona ; Tamm, Ernst R.

; Goepferich, Achim

; Fuchshofer, Rudolf

; Breunig, Miriam

Preview

License: Creative Commons Attribution 4.0
PDF - Published Version
(1MB)

Date of publication of this fulltext: 23 Mar 2022 17:57

Alternative links to fulltext:DOI Publisher Publisher

Details

Preview

Export bibliographical data

Abstract

A root cause for the development and progression of primary open-angle glaucoma might be the loss of the Schlemm’s canal (SC) cell function due to an impaired Angiopoietin-1 (Angpt-1)/Tie2 signaling. Current therapeutic options fail to restore the SC cell function. We propose Angpt-1 mimetic nanoparticles (NPs) that are intended to bind in a multivalent manner to the Tie2 receptor for successful ...