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Angiopoietin-1 Mimetic Nanoparticles for Restoring the Function of Endothelial Cells as Potential Therapeutic for Glaucoma

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Mietzner, Raphael ; Pawlak, Ramona ; Tamm, Ernst R. ; Goepferich, Achim ; Fuchshofer, Rudolf ; Breunig, Miriam
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 23 Mar 2022 17:57


A root cause for the development and progression of primary open-angle glaucoma might be the loss of the Schlemm's canal (SC) cell function due to an impaired Angiopoietin-1 (Angpt-1)/Tie2 signaling. Current therapeutic options fail to restore the SC cell function. We propose Angpt-1 mimetic nanoparticles (NPs) that are intended to bind in a multivalent manner to the Tie2 receptor for successful ...


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