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Angiopoietin-1 Mimetic Nanoparticles for Restoring the Function of Endothelial Cells as Potential Therapeutic for Glaucoma

URN to cite this document:
urn:nbn:de:bvb:355-epub-519852
DOI to cite this document:
10.5283/epub.51985
Mietzner, Raphael ; Pawlak, Ramona ; Tamm, Ernst R. ; Goepferich, Achim ; Fuchshofer, Rudolf ; Breunig, Miriam
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Date of publication of this fulltext: 23 Mar 2022 17:57


Abstract

A root cause for the development and progression of primary open-angle glaucoma might be the loss of the Schlemm’s canal (SC) cell function due to an impaired Angiopoietin-1 (Angpt-1)/Tie2 signaling. Current therapeutic options fail to restore the SC cell function. We propose Angpt-1 mimetic nanoparticles (NPs) that are intended to bind in a multivalent manner to the Tie2 receptor for successful ...

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