Effectiveness of Repetitive Transcranial Magnetic Stimulation in the Treatment of Bipolar Disorder in Comparison to the Treatment of Unipolar Depression in a Naturalistic Setting

URN to cite this document:

urn:nbn:de:bvb:355-epub-519885 Copy

DOI to cite this document:

10.5283/epub.51988 Copy

Alhelali, Abdullah ; Almheiri, Eisa ; Abdelnaim, Mohamed ; Weber, Franziska C. ; Langguth, Berthold ; Schecklmann, Martin ; Hebel, Tobias

Preview	License: Creative Commons Attribution 4.0 PDF - Published Version (566kB)
Preview	License: Creative Commons Attribution 4.0 PDF - Published Version (674kB)

Date of publication of this fulltext: 06 Apr 2022 12:19

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Details

Item type:	Article
Open Access Type:	Gold (with APC)
Höhe Gebühr (aus OpenAPC):	1502.26
Institution der Zahlung:	Regensburg U
Journal or Publication Title:	Brain sciences
Publisher:	MDPI
Place of Publication:	BASEL
Volume:	12
Number of Issue or Book Chapter:	3
Page Range:	p. 298
Date:	23 February 2022
Institutions:	Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number:	Value Type 10.3390/brainsci12030298 DOI
Keywords:	EPIDEMIOLOGY; EFFICACY; BLIND; RTMS; TMS; depression; bipolar disorder; rtms; repetitive transcranial magnetic stimulation; non-invasive brain stimulation; neurostimulation
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	51988

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) is effective in the treatment of depression. However, for the subset of patients with bipolar disorder, less data is available and overall strength of evidence is weaker than for its use in unipolar depression. A cohort of 505 patients (of which 46 had a diagnosis of bipolar disorder) with depression who were treated with rTMS were analyzed ...

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is effective in the treatment of depression. However, for the subset of patients with bipolar disorder, less data is available and overall strength of evidence is weaker than for its use in unipolar depression. A cohort of 505 patients (of which 46 had a diagnosis of bipolar disorder) with depression who were treated with rTMS were analyzed retrospectively with regards to their response to several weeks of treatment. Hamilton Depression Rating Scale (HDRS) was assessed as main outcome. Unipolar and bipolar patients with depression did not differ significantly in baseline demographic variables or severity of depression. Both groups did not differ significantly in their response to treatment as indicated by absolute and relative changes in the HDRS and response and remission rates. On HDRS subitem-analysis, bipolar patients showed superior amelioration of the symptom "paranoid symptoms" in a statistically significant manner. In conclusion, depressed patients with a diagnosis of bipolar disorder benefit from rTMS in a similar fashion as patients with unipolar depression in a naturalistic setting. rTMS might be more effective in reducing paranoia in bipolar than in unipolar patients.

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Metadata last modified: 02 Dec 2022 13:56

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