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Fibronectin Adherent Cell Populations Derived From Avascular and Vascular Regions of the Meniscus Have Enhanced Clonogenicity and Differentiation Potential Under Physioxia

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Pattappa, Girish ; Reischl, Franziska ; Jahns, Judith ; Schewior, Ruth ; Lang, Siegmund ; Zellner, Johannes ; Johnstone, Brian ; Docheva, Denitsa ; Angele, Peter
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 07 Apr 2022 04:54


The meniscus is composed of an avascular inner region and vascular outer region. The vascular region has been shown to contain a progenitor population with multilineage differentiation capacity. Strategies facilitating the isolation and propagation of these progenitors can be used to develop cell-based meniscal therapies. Differential adhesion to fibronectin has been used to isolate progenitor ...


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