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Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors

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Förch, Antonia ; Wallner, Susanne ; Zeman, Florian ; Ettl, Tobias ; Brochhausen, Christoph ; Schreml, Stephan
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 07 Apr 2022 04:58


TWIK-related acid-sensitive potassium channels TASK1 and TASK3, as well as the G-protein-coupled receptors GPR31 and GPR151, are proton-sensitive membrane proteins. They can be activated or inhibited by low extracellular pH (pHe), which is a hallmark of the tumor microenvironment in solid tumors. However, the role of these channels in the development of skin tumors is still unclear. In this ...


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