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Prognostic Value of Perineural Invasion on Survival and Recurrence in Oral Squamous Cell Carcinoma

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Spoerl, Steffen ; Spoerl, Silvia ; Reil, Stephanie ; Gerken, Michael ; Ludwig, Nils ; Taxis, Juergen ; Fischer, René ; Ettl, Tobias ; Reichert, Torsten E. ; Spanier, Gerrit
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 10 May 2022 10:21


A diagnosis of perineural invasion (PNI) is widely accepted as an unfavorable prognostic factor in various solid malignancies. Although PNI has been described as a high-risk parameter in oral squamous cell carcinoma (OSCC), its role in the current staging manuals of the American Joint Committee on Cancer (AJCC) is rather subordinate. We analysed the prognostic value of PNI on survival and ...


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