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Enzyme-triggered antigen release enhances cross presentation by dendritic cells

Stahl, Monika ; Holzinger, Jonas M. ; Bülow, Sigrid ; Goepferich, Achim



Zusammenfassung

Nanoparticles hold great potential as vaccine carriers due to their highly versatile structure and the possibility to influence intracellular trafficking and antigen presentation by their design. In this study, we developed a nanoparticulate system with a new enzyme-triggered antigen release mechanism. For this novel approach, nanoparticle and model antigen ovalbumin were linked with a substrate ...

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