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Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?

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Rupprecht, Rainer ; Wetzel, Christian H. ; Dorostkar, Mario ; Herms, Jochen ; Albert, Nathalie L. ; Schwarzbach, Jens V. ; Schumacher, Michael ; Neumann, Inga D.
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Date of publication of this fulltext: 27 May 2022 07:39


Efficient treatment of stress-related disorders, such as depression, is still a major challenge. The onset of antidepressant drug action is generally quite slow, while the anxiolytic action of benzodiazepines is considerably faster. However, their long-term use is impaired by tolerance development, abuse liability and cognitive impairment. Benzodiazepines act as positive allosteric modulators of ...


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