Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?

URN to cite this document:: urn:nbn:de:bvb:355-epub-523003
DOI to cite this document:: 10.5283/epub.52300

Rupprecht, Rainer

; Wetzel, Christian H.

; Dorostkar, Mario

; Herms, Jochen ; Albert, Nathalie L. ; Schwarzbach, Jens V. ; Schumacher, Michael

; Neumann, Inga D.

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Date of publication of this fulltext: 27 May 2022 07:39

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Abstract

Efficient treatment of stress-related disorders, such as depression, is still a major challenge. The onset of antidepressant drug action is generally quite slow, while the anxiolytic action of benzodiazepines is considerably faster. However, their long-term use is impaired by tolerance development, abuse liability and cognitive impairment. Benzodiazepines act as positive allosteric modulators of ...