Advanced Immune Cell Profiling by Multiparameter Flow Cytometry in Humanized Patient-Derived Tumor Mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-523011
DOI to cite this document:: 10.5283/epub.52301

Bruss, Christina ; Kellner, Kerstin ; Ortmann, Olaf

; Seitz, Stephan ; Brockhoff, Gero

; Hutchinson, James A.

; Wege, Anja Kathrin

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Date of publication of this fulltext: 25 May 2022 11:45

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Abstract

“Humanized” mice have been widely used for the characterization of human cancer progression and as a powerful preclinical model. Standardization of multicolor phenotyping could help to identify immune cell patterns involved in checkpoint-related complications. Therefore, we applied established protocols for immune cell profiling to our humanized Patient-Derived Xenograft (hPDX) model. hPDX are ...