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Advanced Immune Cell Profiling by Multiparameter Flow Cytometry in Humanized Patient-Derived Tumor Mice

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Bruss, Christina ; Kellner, Kerstin ; Ortmann, Olaf ; Seitz, Stephan ; Brockhoff, Gero ; Hutchinson, James A. ; Wege, Anja Kathrin
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 May 2022 11:45


“Humanized” mice have been widely used for the characterization of human cancer progression and as a powerful preclinical model. Standardization of multicolor phenotyping could help to identify immune cell patterns involved in checkpoint-related complications. Therefore, we applied established protocols for immune cell profiling to our humanized Patient-Derived Xenograft (hPDX) model. hPDX are ...


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