Multiplex gene analysis reveals T-cell and antibody-mediated rejection-specific upregulation of complement in renal transplants

URN to cite this document:: urn:nbn:de:bvb:355-epub-523315
DOI to cite this document:: 10.5283/epub.52331

Vonbrunn, Eva ; Ries, Tajana ; Söllner, Stefan ; Müller-Deile, Janina ; Büttner-Herold, Maike ; Amann, Kerstin ; Daniel, Christoph

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Date of publication of this fulltext: 24 May 2022 13:08

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Abstract

In renal transplantation, complement is involved in ischemia reperfusion injury, graft rejection and dysfunction. However, it is still unclear how induction of complement and its activation are initiated. Using allograft biopsies of a well-characterized cohort of 28 renal transplant patients with no rejection (Ctrl), delayed graft function (DGF), acute T-cell-mediated (TCMR) or antibody-mediated ...