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Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study

Steinbrenner, Inga ; Sekula, Peggy ; Kotsis, Fruzsina ; von Cube, Maja ; Cheng, Yurong ; Nadal, Jennifer ; Schmid, Matthias ; Schneider, Markus P ; Krane, Vera ; Nauck, Matthias ; Eckardt, Kai-Uwe ; Schultheiss, Ulla T ; Eckardt, Kai-Uwe ; Meiselbach, Heike ; Schneider, Markus P ; Schiffer, Mario ; Prokosch, Hans-Ulrich ; Bärthlein, Barbara ; Beck, Andreas ; Reis, André ; Ekici, Arif B ; Becker, Susanne ; Becker-Grosspitsch, Dinah ; Alberth-Schmidt, Ulrike ; Hausknecht, Birgit ; Weigel, Anke ; Walz, Gerd ; Köttgen, Anna ; Schultheiß, Ulla T ; Kotsis, Fruzsina ; Meder, Simone ; Mitsch, Erna ; Reinhard, Ursula ; Floege, Jürgen ; Saritas, Turgay ; Schaeffner, Elke ; Baid-Agrawal, Seema ; Theisen, Kerstin ; Haller, Hermann ; Menne, Jan ; Zeier, Martin ; Sommerer, Claudia ; Theilinger, Johanna ; Wolf, Gunter ; Busch, Martin ; Paul, Rainer ; Sitter, Thomas ; Wanner, Christoph ; Krane, Vera ; Börner-Klein, Antje ; Bauer, Britta ; Kronenberg, Florian ; Raschenberger, Julia ; Kollerits, Barbara ; Forer, Lukas ; Schönherr, Sebastian ; Weissensteiner, Hansi ; Oefner, Peter ; Gronwald, Wolfram ; Schmid, Matthias ; Nadal, Jennifer



Abstract

Background: Osteopontin (OPN), synthesized in the thick ascending limb of Henle's loop and in the distal tubule, is involved in the pathogenesis of kidney fibrosis, a hallmark of kidney failure (KF). In a cohort of chronic kidney disease (CKD) patients, we evaluated OPN's association with kidney markers and KF. Methods: OPN was measured from baseline serum samples of German Chronic Kidney ...

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