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Synthesis of Unnatural α‑Amino Acid Derivatives via Photoredox Activation of Inert C(sp3)−H Bonds

Babawale, Florence ; Murugesan, Kathiravan ; Narobe, Rok ; König, Burkhard



Abstract

The synthesis of unnatural, tertiary amino acids is a challenging task. While decarboxylation−radical addition has been an important strategy for their formation, the use of alkyl radicals from C(sp3)−H bonds has not been fully explored. Herein, we report a photocatalytic protocol for the synthesis of unnatural α-amino esters employing abundant alkanes and imines retaining full atom economy. When this method is applied, several amino acid derivatives are synthesized in moderate to good yields.


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