Molecular insights into intra-complex signal transmission during stressosome activation

URN to cite this document:: urn:nbn:de:bvb:355-epub-525262
DOI to cite this document:: 10.5283/epub.52526

Miksys, Algirdas ; Fu, Lifei ; Madej, M. Gregor

; Guerreiro, Duarte N. ; Kaltwasser, Susann ; Conway, Maria ; Ejder, Sema ; Bruckmann, Astrid

; Marles-Wright, Jon ; Lewis, Richard J. ; O’Byrne, Conor ; Pané-Farré, Jan ; Ziegler, Christine

Preview

License: Creative Commons Attribution 4.0
PDF - Published Version
(6MB)

Date of publication of this fulltext: 01 Jul 2022 06:07

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

The stressosome is a pseudo-icosahedral megadalton bacterial stress-sensing protein complex consisting of several copies of two STAS-domain proteins, RsbR and RsbS, and the kinase RsbT. Upon perception of environmental stress multiple copies of RsbT are released from the surface of the stressosome. Free RsbT activates downstream proteins to elicit a global cellular response, such as the ...