Molecular insights into intra-complex signal transmission during stressosome activation

URN to cite this document:: urn:nbn:de:bvb:355-epub-525262
DOI to cite this document:: 10.5283/epub.52526

Miksys, Algirdas ; Fu, Lifei ; Madej, M. Gregor

; Guerreiro, Duarte N. ; Kaltwasser, Susann ; Conway, Maria ; Ejder, Sema ; Bruckmann, Astrid

; Marles-Wright, Jon ; Lewis, Richard J. ; O’Byrne, Conor ; Pané-Farré, Jan ; Ziegler, Christine

Preview

License: Creative Commons Attribution 4.0
PDF - Published Version
(6MB)

Date of publication of this fulltext: 01 Jul 2022 06:07

Alternative links to fulltext:DOI Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

Cryo-EM structures of the stress-sensing complex in Listeria innocua reveal conformational changes that initiate the signaling response to environmental stress. The stressosome is a pseudo-icosahedral megadalton bacterial stress-sensing protein complex consisting of several copies of two STAS-domain proteins, RsbR and RsbS, and the kinase RsbT. Upon perception of environmental stress multiple ...