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Molecular insights into intra-complex signal transmission during stressosome activation

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Miksys, Algirdas ; Fu, Lifei ; Madej, M. Gregor ; Guerreiro, Duarte N. ; Kaltwasser, Susann ; Conway, Maria ; Ejder, Sema ; Bruckmann, Astrid ; Marles-Wright, Jon ; Lewis, Richard J. ; O’Byrne, Conor ; Pané-Farré, Jan ; Ziegler, Christine
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 01 Jul 2022 06:07


The stressosome is a pseudo-icosahedral megadalton bacterial stress-sensing protein complex consisting of several copies of two STAS-domain proteins, RsbR and RsbS, and the kinase RsbT. Upon perception of environmental stress multiple copies of RsbT are released from the surface of the stressosome. Free RsbT activates downstream proteins to elicit a global cellular response, such as the ...


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