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CCN2/CTGF—A Modulator of the Optic Nerve Head Astrocyte

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Dillinger, Andrea E. ; Weber, Gregor R. ; Mayer, Matthias ; Schneider, Magdalena ; Göppner, Corinna ; Ohlmann, Andreas ; Shamonin, Mikhail ; Monkman, Gareth J. ; Fuchshofer, Rudolf
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 07 Jul 2022 14:27


In primary open-angle glaucoma (POAG), a neurodegenerative disease of the optic nerve (ON) and leading cause of blindness, the optic nerve head (ONH) undergoes marked structural extracellular matrix (ECM) changes, which contribute to its permanent deformation and to degeneration of ON axons. The remodeling process of the ECM causes changes in the biomechanical properties of the ONH and the ...


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