Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26

URN to cite this document:: urn:nbn:de:bvb:355-epub-525930
DOI to cite this document:: 10.5283/epub.52593

Salerno-Kochan, Anna

; Horn, Andreas ; Ghosh, Pritha ; Nithin, Chandran

; Kościelniak, Anna ; Meindl, Andreas ; Strauss, Daniela ; Krutyhołowa, Rościsław

; Rossbach, Oliver

; Bujnicki, Janusz M ; Gaik, Monika

; Medenbach, Jan

; Glatt, Sebastian

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Date of publication of this fulltext: 14 Jul 2022 06:10

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Abstract

The TRIM-NHL protein Meiotic P26 (Mei-P26) acts as a regulator of cell fate in Drosophila. Its activity is critical for ovarian germline stem cell maintenance, differentiation of oocytes, and spermatogenesis. Mei-P26 functions as a post-transcriptional regulator of gene expression; however, the molecular details of how its NHL domain selectively recognizes and regulates its mRNA targets have ...