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Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26

URN to cite this document:
urn:nbn:de:bvb:355-epub-525930
DOI to cite this document:
10.5283/epub.52593
Salerno-Kochan, Anna ; Horn, Andreas ; Ghosh, Pritha ; Nithin, Chandran ; Kościelniak, Anna ; Meindl, Andreas ; Strauss, Daniela ; Krutyhołowa, Rościsław ; Rossbach, Oliver ; Bujnicki, Janusz M ; Gaik, Monika ; Medenbach, Jan ; Glatt, Sebastian
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Date of publication of this fulltext: 14 Jul 2022 06:10


Abstract

The TRIM-NHL protein Meiotic P26 (Mei-P26) acts as a regulator of cell fate in Drosophila. Its activity is critical for ovarian germline stem cell maintenance, differentiation of oocytes, and spermatogenesis. Mei-P26 functions as a post-transcriptional regulator of gene expression; however, the molecular details of how its NHL domain selectively recognizes and regulates its mRNA targets have ...

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