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Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26

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Salerno-Kochan, Anna ; Horn, Andreas ; Ghosh, Pritha ; Nithin, Chandran ; Kościelniak, Anna ; Meindl, Andreas ; Strauss, Daniela ; Krutyhołowa, Rościsław ; Rossbach, Oliver ; Bujnicki, Janusz M ; Gaik, Monika ; Medenbach, Jan ; Glatt, Sebastian
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 14 Jul 2022 06:10


The TRIM-NHL protein Meiotic P26 (Mei-P26) acts as a regulator of cell fate in Drosophila. Its activity is critical for ovarian germline stem cell maintenance, differentiation of oocytes, and spermatogenesis. Mei-P26 functions as a post-transcriptional regulator of gene expression; however, the molecular details of how its NHL domain selectively recognizes and regulates its mRNA targets have ...


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