HuH-7-Lunet BLR Cells Propagate Rat Hepatitis E Virus (HEV) in a Cell Culture System Optimized for HEV

URN to cite this document:: urn:nbn:de:bvb:355-epub-525970
DOI to cite this document:: 10.5283/epub.52597

Schemmerer, Mathias

; Erl, Monika ; Wenzel, Jürgen J.

Preview

License: Creative Commons Attribution 4.0
PDF - Published Version
(753kB)

Date of publication of this fulltext: 14 Jul 2022 07:48

Alternative links to fulltext:DOI Publisher Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

The family Hepeviridae comprises the species Orthohepevirus A-D (HEV-A to -D). HEV-C genotype 1 (HEV-C1, rat HEV) is able to infect humans. This study investigated whether an optimized HEV-A cell culture system is able to propagate the cell culture-derived rat HEV, and if de novo isolation of the virus from rat liver is possible. We tested the liver carcinoma cell lines PLC/PRF/5, HuH-7, and ...