Time Trend in SARS-CoV-2 Seropositivity, Surveillance Detection- and Infection Fatality Ratio until Spring 2021 in the Tirschenreuth County—Results from a Population-Based Longitudinal Study in Germany

URN to cite this document:

urn:nbn:de:bvb:355-epub-526134 Copy

DOI to cite this document:

10.5283/epub.52613 Copy

Einhauser, Sebastian ; Peterhoff, David ; Beileke, Stephanie ; Günther, Felix ; Niller, Hans-Helmut ; Steininger, Philipp ; Knöll, Antje ; Korn, Klaus ; Berr, Melanie ; Schütz, Anja ; Wiegrebe, Simon ; Stark, Klaus J. ; Gessner, André ; Burkhardt, Ralph ; Kabesch, Michael ; Schedl, Holger ; Küchenhoff, Helmut ; Pfahlberg, Annette B. ; Heid, Iris M. ; Gefeller, Olaf ; Überla, Klaus ; Wagner, Ralf

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Date of publication of this fulltext: 26 Jul 2022 09:13

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Details

Item type:	Article
Open Access Type:	Gold (with APC)
Höhe Gebühr (aus OpenAPC):	2317.75
Institution der Zahlung:	Regensburg U
Journal or Publication Title:	Viruses
Publisher:	MDPI
Place of Publication:	BASEL
Volume:	14
Number of Issue or Book Chapter:	6
Page Range:	p. 1168
Date:	27 May 2022
Institutions:	Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie
Identification Number:	Value Type 10.3390/v14061168 DOI
Keywords:	IMMUNOGENICITY; IMPACT; SARS-CoV-2; seroprevalence; infection fatality ratio; case fatality ratio; surveillance detection ratio; senior care homes; elderly; vaccination; population-based; longitudinal
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	52613

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Abstract

Herein, we provide results from a prospective population-based longitudinal follow-up (FU) SARS-CoV-2 serosurveillance study in Tirschenreuth, the county which was hit hardest in Germany in spring 2020 and early 2021. Of 4203 individuals aged 14 years or older enrolled at baseline (BL, June 2020), 3546 participated at FU1 (November 2020) and 3391 at FU2 (April 2021). Key metrics comprising ...

Abstract

Herein, we provide results from a prospective population-based longitudinal follow-up (FU) SARS-CoV-2 serosurveillance study in Tirschenreuth, the county which was hit hardest in Germany in spring 2020 and early 2021. Of 4203 individuals aged 14 years or older enrolled at baseline (BL, June 2020), 3546 participated at FU1 (November 2020) and 3391 at FU2 (April 2021). Key metrics comprising standardized seroprevalence, surveillance detection ratio (SDR), infection fatality ratio (IFR) and success of the vaccination campaign were derived using the Roche N- and S-Elecsys anti-SARS-CoV-2 test together with a self-administered questionnaire. N-seropositivity at BL was 9.2% (1st wave). While we observed a low new seropositivity between BL and FU1 (0.9%), the combined 2nd and 3rd wave accounted for 6.1% new N-seropositives between FU1 and FU2 (ever seropositives at FU2: 15.4%). The SDR decreased from 5.4 (BL) to 1.1 (FU2) highlighting the success of massively increased testing in the population. The IFR based on a combination of serology and registration data resulted in 3.3% between November 2020 and April 2021 compared to 2.3% until June 2020. Although IFRs were consistently higher at FU2 compared to BL across age-groups, highest among individuals aged 70+ (18.3% versus 10.7%, respectively), observed differences were within statistical uncertainty bounds. While municipalities with senior care homes showed a higher IFR at BL (3.0% with senior care home vs. 0.7% w/o), this effect diminished at FU2 (3.4% vs. 2.9%). In April 2021 (FU2), vaccination rate in the elderly was high (>77.4%, age-group 80+).

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Metadata last modified: 27 Jun 2024 12:29

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