Hereditary Diffuse Gastric Cancer: Molecular Genetics, Biological Mechanisms and Current Therapeutic Approaches

URN to cite this document:: urn:nbn:de:bvb:355-epub-527523
DOI to cite this document:: 10.5283/epub.52752

Cosma, Lidia-Sabina ; Schlosser, Sophie ; Tews, Hauke C. ; Müller, Martina ; Kandulski, Arne

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 17 Aug 2022 08:06

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Abstract

Hereditary diffuse gastric cancer is an autosomal dominant syndrome characterized by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is caused by inactivating mutations in the tumor suppressor gene CDH1. Genetic testing technologies have become more efficient over the years, also enabling the discovery of other susceptibility genes for gastric cancer, such as CTNNA1 ...