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Tigecycline Soft Tissue Penetration in Obese and Non-obese Surgical Patients Determined by Using In Vivo Microdialysis

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Dorn, Christoph ; Petroff, David ; Kratzer, Alexander ; Kees, Frieder ; Kloft, Charlotte ; Zeitlinger, Markus ; Wrigge, Hermann ; Simon, Philipp
Date of publication of this fulltext: 25 Aug 2022 04:27

This publication is part of the DEAL contract with Springer.


Background and Objective Tigecycline, a broad-spectrum glycylcycline antibiotic, is approved for use at a fixed dose irrespective of body weight. However, its pharmacokinetics may be altered in obesity, which would impact on the antibiotic's effectiveness. The objective of this study was to investigate the plasma and subcutaneous tissue concentrations of tigecycline in obese patients compared ...


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