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Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19

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Niederreiter, Janina ; Eck, Christine ; Ries, Tajana ; Hartmann, Arndt ; Märkl, Bruno ; Büttner-Herold, Maike ; Amann, Kerstin ; Daniel, Christoph
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 31 Aug 2022 16:46


Complement plays an important role in the direct defense to pathogens, but can also activate immune cells and the release of pro-inflammatory cytokines. However, in critically ill patients with COVID-19 the immune system is inadequately activated leading to severe acute respiratory syndrome (SARS) and acute kidney injury, which is associated with higher mortality. Therefore, we characterized ...


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