Enhanced nucleosome assembly at CpG sites containing an extended 5-methylcytosine analogue

URN to cite this document:: urn:nbn:de:bvb:355-epub-528828
DOI to cite this document:: 10.5283/epub.52882

Tomkuvienė, Miglė ; Meier, Markus ; Ikasalaitė, Diana ; Wildenauer, Julia ; Kairys, Visvaldas ; Klimašauskas, Saulius ; Manelyte, Laura

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Date of publication of this fulltext: 16 Sep 2022 09:37

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Abstract

Methylation of cytosine to 5-methylcytosine (mC) at CpG sites is a prevalent reversible epigenetic mark in vertebrates established by DNA methyltransferases (MTases); the attached methyl groups can alter local structure of DNA and chromatin as well as binding of dedicated proteins. Nucleosome assembly on methylated DNA has been studied extensively, however little is known how the chromatin ...