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Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation

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Scholz, Julia Katharina ; Kraus, Andre ; Lüder, Dominik ; Skoczynski, Kathrin ; Schiffer, Mario ; Schödel, Johannes ; Buchholz, Björn
Date of publication of this fulltext: 20 Oct 2022 07:16


Autosomal dominant polycystic kidney disease is the most common monogenic disease that causes end-stage renal failure. It primarily results from mutations in the PKD1 gene that encodes for Polycystin-1. How loss of Polycystin-1 translates into bilateral renal cyst development is mostly unknown. cAMP is significantly involved in cyst enlargement but its role in cyst initiation has remained ...


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