Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation

URN to cite this document:: urn:nbn:de:bvb:355-epub-530646
DOI to cite this document:: 10.5283/epub.53064

Scholz, Julia Katharina ; Kraus, Andre ; Lüder, Dominik ; Skoczynski, Kathrin ; Schiffer, Mario ; Schödel, Johannes ; Buchholz, Björn

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 20 Oct 2022 07:16

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Abstract

Autosomal dominant polycystic kidney disease is the most common monogenic disease that causes end-stage renal failure. It primarily results from mutations in the PKD1 gene that encodes for Polycystin-1. How loss of Polycystin-1 translates into bilateral renal cyst development is mostly unknown. cAMP is significantly involved in cyst enlargement but its role in cyst initiation has remained ...