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Transient Retention of Photoreceptor Outer Segments in Matrigel-Embedded Retinal Organoids

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Berber, Patricia ; Bondarenko, Sofiia ; Michaelis, Lisa ; Weber, Bernhard Heinrich Friedrich
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Date of publication of this fulltext: 14 Dec 2022 13:13


Retinal organoids (ROs) are three-dimensional retinal tissues, which are differentiated in vitro from induced pluripotent stem cells (iPSC), ultimately forming all main retinal cell types under defined culture conditions. ROs show several highly specialized retinal features, including the outgrowth of photoreceptor outer segments (OSs). In vivo, the photoreceptor OSs are enveloped and maintained ...


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