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Investigation of the Impact of Hydrolytically Cleavable Groups on the Stability of Poly(ethylene glycol) Based Hydrogels Cross-Linked via the Inverse Electron Demand Diels-Alder (iEDDA) Reaction

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Ziegler, Christian ; Graf, Moritz ; Nagaoka, Makoto ; Goepferich, Achim
Date of publication of this fulltext: 19 Dec 2022 07:47

This publication is part of the DEAL contract with Wiley.


Eight-armed poly(ethylene glycol) (PEG) hydrogels cross-linked via inverse electron demand Diels-Alder reaction between norbornene and tetrazine groups are promising materials for long-term protein delivery. While a controlled release over 265 days is achieved for 15% w/v hydrogels in the previous study, the material shows high stability over 500 days despite having cleavable ester linkages ...


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