How clathrin-coated pits control nanoparticle avidity for cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-535117
DOI to cite this document:: 10.5283/epub.53511

Zimmer, Oliver

; Goepferich, Achim

License: Creative Commons Attribution Non-commercial 3.0
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Date of publication of this fulltext: 11 Jan 2023 08:48

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Abstract

The paramount relevance of clathrin-coated pits (CCPs) to receptor-mediated endocytosis of nanoparticles, extracellular vesicles, and viruses has made them the focus of many studies; however, the role of CCP geometry in the ligand–receptor interactions between multivalent nanoparticles and cells has not been investigated. We hypothesized the general dependence of nanoparticle binding energy on ...