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How clathrin-coated pits control nanoparticle avidity for cells

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Zimmer, Oliver ; Goepferich, Achim
Date of publication of this fulltext: 11 Jan 2023 08:48


The paramount relevance of clathrin-coated pits (CCPs) to receptor-mediated endocytosis of nanoparticles, extracellular vesicles, and viruses has made them the focus of many studies; however, the role of CCP geometry in the ligand–receptor interactions between multivalent nanoparticles and cells has not been investigated. We hypothesized the general dependence of nanoparticle binding energy on ...


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