Expression of pH-Sensitive TRPC4 in Common Skin Tumors

URN to cite this document:: urn:nbn:de:bvb:355-epub-535244
DOI to cite this document:: 10.5283/epub.53524

Kurz, Bernadett ; Michael, Hannah Philine ; Förch, Antonia

; Wallner, Susanne ; Zeman, Florian ; Decking, Sonja-Maria ; Ugele, Ines ; Hintschich, Constantin

; Haubner, Frank ; Ettl, Tobias

; Renner, Kathrin

; Brochhausen, Christoph

; Schreml, Stephan

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Jan 2023 14:19

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Abstract

TRPCs (transient receptor potential classical or cation channels) play a crucial role in tumor biology, especially in the Ca2+ homeostasis in cancer cells. TRPC4 is a pH-sensitive member of this family of proteins. As solid tumors exhibit an inversed pH-gradient with lowered extracellular and increased intracellular pH, both contributing to tumor progression, TRPC4 might be a signaling molecule ...