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IFN-γ-Based ELISpot as a New Tool to Detect Human Infections with Borna Disease Virus 1 (BoDV-1): A Pilot Study

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Eidenschink, Lisa ; Knoll, Gertrud ; Tappe, Dennis ; Offner, Robert ; Drasch, Thomas ; Ehrl, Yvonne ; Banas, Bernhard ; Banas, Miriam C. ; Niller, Hans Helmut ; Gessner, André ; Köstler, Josef ; Lampl, Benedikt M. J. ; Pregler, Matthias ; Völkl, Melanie ; Kunkel, Jürgen ; Neumann, Bernhard ; Angstwurm, Klemens ; Schmidt, Barbara ; Bauswein, Markus
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Jan 2023 11:52


More than 40 human infections with the zoonotic Borna disease virus 1 (BoDV-1) have been reported to German health authorities from endemic regions in southern and eastern Germany. Diagnosis of a confirmed case is based on the detection of BoDV-1 RNA or BoDV-1 antigen. In parallel, serological assays such as ELISA, immunoblots, and indirect immunofluorescence are in use to detect the ...


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