Human Infections with Borna Disease Virus 1 (BoDV-1) Primarily Lead to Severe Encephalitis: Further Evidence from the Seroepidemiological BoSOT Study in an Endemic Region in Southern Germany

URN to cite this document:

urn:nbn:de:bvb:355-epub-535316 Copy

DOI to cite this document:

10.5283/epub.53531 Copy

Bauswein, Markus ; Eidenschink, Lisa ; Knoll, Gertrud ; Neumann, Bernhard ; Angstwurm, Klemens ; Zoubaa, Saida ; Riemenschneider, Markus J. ; Lampl, Benedikt M. J. ; Pregler, Matthias ; Niller, Hans Helmut ; Jantsch, Jonathan ; Gessner, André ; Eberhardt, Yvonne ; Huppertz, Gunnar ; Schramm, Torsten ; Kühn, Stefanie ; Koller, Michael ; Drasch, Thomas ; Ehrl, Yvonne ; Banas, Bernhard ; Offner, Robert ; Schmidt, Barbara ; Banas, Miriam C.

License: Creative Commons Attribution 4.0 PDF - Published Version (1MB)

Date of publication of this fulltext: 12 Jan 2023 14:01

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Details

Item type:	Article
Open Access Type:	Gold (with APC)
Höhe Gebühr (aus OpenAPC):	2598.09
Institution der Zahlung:	Regensburg U
Journal or Publication Title:	Viruses
Publisher:	MDPI
Volume:	15
Number of Issue or Book Chapter:	1
Page Range:	p. 188
Date:	9 January 2023
Institutions:	Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Neurologie Medicine > Abteilung für Neuropathologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien Medicine > Institut für Epidemiologie und Präventivmedizin
Identification Number:	Value Type 10.3390/v15010188 DOI
Keywords:	Borna disease virus 1 (BoDV-1); epidemiology; encephalitis; diagnostics; ELISA; indirect immunofluorescence assay (iIFA); solid organ transplantation; linear epitope mapping; molecular mimicry; endogenous Borna-like elements
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	53531

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Abstract

More than 40 human cases of severe encephalitis caused by Borna disease virus 1 (BoDV-1) have been reported to German health authorities. In an endemic region in southern Germany, we conducted the seroepidemiological BoSOT study (“BoDV-1 after solid-organ transplantation”) to assess whether there are undetected oligo- or asymptomatic courses of infection. A total of 216 healthy blood donors and ...

Abstract

More than 40 human cases of severe encephalitis caused by Borna disease virus 1 (BoDV-1) have been reported to German health authorities. In an endemic region in southern Germany, we conducted the seroepidemiological BoSOT study (“BoDV-1 after solid-organ transplantation”) to assess whether there are undetected oligo- or asymptomatic courses of infection. A total of 216 healthy blood donors and 280 outpatients after solid organ transplantation were screened by a recombinant BoDV-1 ELISA followed by an indirect immunofluorescence assay (iIFA) as confirmatory test. For comparison, 288 serum and 258 cerebrospinal fluid (CSF) samples with a request for tick-borne encephalitis (TBE) diagnostics were analyzed for BoDV-1 infections. ELISA screening reactivity rates ranged from 3.5% to 18.6% depending on the cohort and the used ELISA antigen, but only one sample of a patient from the cohort with requested TBE diagnostics was confirmed to be positive for anti-BoDV-1-IgG by iIFA. In addition, the corresponding CSF sample of this patient with a three-week history of severe neurological disease tested positive for BoDV-1 RNA. Due to the iIFA results, all other results were interpreted as false-reactive in the ELISA screening. By linear serological epitope mapping, cross-reactions with human and bacterial proteins were identified as possible underlying mechanism for the false-reactive ELISA screening results. In conclusion, no oligo- or asymptomatic infections were detected in the studied cohorts. Serological tests based on a single recombinant BoDV-1 antigen should be interpreted with caution, and an iIFA should always be performed in addition.

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Metadata last modified: 22 Apr 2024 09:16

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