Influence of Single-Nucleotide Polymorphisms on Vitamin D Receptor Expression in Periodontal Ligament Fibroblasts as a Response to Orthodontic Compression

URN to cite this document:: urn:nbn:de:bvb:355-epub-535839
DOI to cite this document:: 10.5283/epub.53583

Küchler, Erika Calvano ; Schröder, Agnes ; Spanier, Gerrit ; Thedei, Geraldo ; Carvalho Ribeiro de Oliveira, Maria Beatriz ; de Menezes-Oliveira, Maria Angélica Hueb ; Proff, Peter ; Kirschneck, Christian

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Date of publication of this fulltext: 20 Jan 2023 06:11

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Abstract

This study aimed to evaluate if single-nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene are associated with gene expression in human periodontal ligament (hPDL) fibroblasts under simulated orthodontic compressive force. hPDL samples from 57 patients were used. A physiological compressive strain was performed to simulate orthodontic tooth movement in pressure areas under cell ...