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Influence of Single-Nucleotide Polymorphisms on Vitamin D Receptor Expression in Periodontal Ligament Fibroblasts as a Response to Orthodontic Compression

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Küchler, Erika Calvano ; Schröder, Agnes ; Spanier, Gerrit ; Thedei, Geraldo ; Carvalho Ribeiro de Oliveira, Maria Beatriz ; de Menezes-Oliveira, Maria Angélica Hueb ; Proff, Peter ; Kirschneck, Christian
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Date of publication of this fulltext: 20 Jan 2023 06:11


This study aimed to evaluate if single-nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene are associated with gene expression in human periodontal ligament (hPDL) fibroblasts under simulated orthodontic compressive force. hPDL samples from 57 patients were used. A physiological compressive strain was performed to simulate orthodontic tooth movement in pressure areas under cell ...


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